|
KMID : 0620920190510100115
|
|
Experimental & Molecular Medicine
2019 Volume.51 No. 10 p.115 ~ p.115
|
|
|
A prognostic index based on an eleven gene signature to predict systemic recurrences in colorectal cancer
|
|
Kim Seon-Kyu
Kim Seon-Young
Kim Chan-Wook
Roh Seon-Ae
Ha Ye-Jin
Lee Jong-Lyul
Heo Hae-Jeong
Cho Dong-Hyung
Lee Ju-Seog
Kim Yong-Sung
Kim Jin-Cheon
|
|
|
Abstract
|
|
|
|
Approximately half of colorectal cancer (CRC) patients experience disease recurrence and metastasis, and these individuals frequently fail to respond to treatment due to their clinical and biological diversity. Here, we aimed to identify a prognostic signature consisting of a small gene group for precisely predicting CRC heterogeneity. We performed transcriptomic profiling using RNA-seq data generated from the primary tissue samples of 130 CRC patients. A prognostic index (PI) based on recurrence-associated genes was developed and validated in two larger independent CRC patient cohorts (n?=?795). The association between the PI and prognosis of CRC patients was evaluated using Kaplan?Meier plots, log-rank tests, a Cox regression analysis and a RT-PCR analysis. Transcriptomic profiling in 130 CRC patients identified two distinct subtypes associated with systemic recurrence. Pathway enrichment and RT-PCR analyses revealed an eleven gene signature incorporated into the PI system, which was a significant prognostic indicator of CRC. Multivariate and subset analyses showed that PI was an independent risk factor (HR?=?1.812, 95% CI?=?1.342?2.448, P?
|
|
|
KEYWORD
|
|
|
Cancer genomics, Colorectal cancer, Prognostic markers
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|